Tatsuya Morimoto Selected Research

Histone Acetyltransferases (Histone Acetyltransferase)

6/2022	Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex.
7/2021	Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats.
1/2016	[Functional Analysis of GATA4 Complex, a Cardiac Hypertrophy-response Transcriptional Factor, Using a Proteomics Approach].
1/2014	Optimal dose-setting study of curcumin for improvement of left ventricular systolic function after myocardial infarction in rats.
1/2013	Application of curcumin to heart failure therapy by targeting transcriptional pathway in cardiomyocytes.
1/2012	A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.
1/2011	A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats.
3/2010	Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
3/2008	The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats.
2/2006	Histone acetyltransferase activity of p300 is required for the promotion of left ventricular remodeling after myocardial infarction in adult mice in vivo.

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Tatsuya Morimoto Research Topics

Disease

32	Heart Failure 06/2022 - 06/2003
24	Hypertrophy 06/2022 - 03/2002
15	Cardiomegaly (Heart Hypertrophy) 01/2022 - 01/2004
10	Myocardial Infarction 01/2022 - 11/2004
9	Fibrosis (Cirrhosis) 01/2022 - 01/2011
4	Coronary Artery Disease (Coronary Atherosclerosis) 04/2022 - 11/2010
4	Atherosclerosis 04/2022 - 01/2011
4	Neoplasms (Cancer) 01/2021 - 03/2004
4	Obesity 01/2020 - 01/2011
4	Heart Diseases (Heart Disease) 01/2018 - 01/2004
3	Hypertension (High Blood Pressure) 07/2021 - 04/2010
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2020 - 01/2012
3	Insulin Resistance 01/2020 - 02/2010
3	Inflammation (Inflammations) 07/2019 - 01/2007
3	Weight Gain 10/2018 - 11/2016
3	Hypercholesterolemia 12/2016 - 01/2007
2	Left Ventricular Dysfunction 11/2021 - 01/2015
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 07/2021 - 02/2021
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 02/2010
2	Glucose Intolerance 01/2019 - 01/2010
2	Abdominal Obesity 01/2018 - 11/2016
2	Dyslipidemias (Dyslipidemia) 01/2015 - 01/2011
1	Cardiotoxicity 01/2022
1	Periodontal Diseases (Periodontal Disease) 11/2021
1	Body Weight (Weight, Body) 01/2020
1	Chronic Renal Insufficiency 11/2019
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Hemorrhage 06/2018
1	Atrial Fibrillation 06/2018
1	Retinoblastoma (Glioblastoma, Retinal) 01/2016
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2016

Drug/Important Bio-Agent (IBA)

15	CurcuminIBA 06/2022 - 03/2008
10	Histone Acetyltransferases (Histone Acetyltransferase)IBA 06/2022 - 02/2006
9	Proteins (Proteins, Gene)FDA Link 04/2022 - 05/2003
9	Transcription Factors (Transcription Factor)IBA 12/2016 - 05/2003
8	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 06/2022 - 09/2004
5	oxidized low density lipoproteinIBA 01/2019 - 01/2011
4	Histones (Histone)IBA 01/2022 - 01/2020
4	Biological ProductsIBA 02/2021 - 06/2003
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2010
3	AdipokinesIBA 04/2022 - 01/2018
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 03/2004
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2021
3	Messenger RNA (mRNA)IBA 01/2022 - 04/2010
3	GATA4 Transcription FactorIBA 01/2022 - 03/2002
3	SaltsIBA 07/2021 - 03/2008
3	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 01/2015
3	Biomarkers (Surrogate Marker)IBA 10/2018 - 01/2007
3	DNA (Deoxyribonucleic Acid)IBA 04/2008 - 02/2006
2	AngiopoietinsIBA 04/2022 - 04/2013
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022 - 02/2021
2	TeaIBA 11/2021 - 01/2020
2	zerumboneIBA 11/2021 - 02/2021
2	Rosuvastatin Calcium (Crestor)FDA Link 01/2021 - 12/2016
2	pitavastatin (itavastatin)FDA Link 01/2021 - 12/2016
2	Mitogen-Activated Protein Kinase 3IBA 11/2020 - 03/2002
2	PolyphenolsIBA 11/2020 - 01/2018
2	1,5- bis(3,5- bis(methoxymethoxy)phenyl)penta- 1,4- dien- 3- oneIBA 01/2020 - 12/2017
2	Triglycerides (Triacylglycerol)IBA 01/2020 - 01/2011
2	AcetyltransferasesIBA 01/2020 - 02/2006
2	LipidsIBA 01/2020 - 01/2011
2	Lipoproteins (Lipoprotein)IBA 11/2016 - 01/2016
2	CyclinsIBA 01/2016 - 03/2010
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2016 - 01/2012
2	SolventsIBA 01/2014 - 01/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2011 - 02/2010
2	Hemoglobins (Hemoglobin)IBA 01/2011 - 01/2010
2	Endothelin-1 (Endothelin 1)IBA 11/2004 - 03/2002
1	pyrazoleIBA 06/2022
1	AnthracyclinesIBA 01/2022
1	Docosahexaenoic AcidsIBA 01/2022
1	Eicosapentaenoic AcidIBA 01/2022
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 12/2021
1	sarpogrelateIBA 12/2021
1	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 12/2021
1	Atrial Natriuretic Factor (ANF)IBA 11/2021
1	CollagenIBA 11/2021
1	Metformin (Glucophage)FDA LinkGeneric 10/2021
1	Coenzyme A (CoA)IBA 01/2021
1	mangostinIBA 01/2021
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 11/2020
1	Nicotinamide MononucleotideIBA 01/2020
1	Catechin (Z 7300)IBA 01/2020
1	SirtuinsIBA 01/2020
1	Cystatin CIBA 11/2019
1	Lysine (L-Lysine)FDA Link 01/2019
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2019
1	Sirtuin 1IBA 01/2019
1	apixabanIBA 06/2018
1	Phenol (Carbolic Acid)FDA Link 04/2018
1	DiarylheptanoidsIBA 04/2018
1	LectinsIBA 01/2018
1	LDL Receptors (LDL Receptor)IBA 01/2018
1	AdiponectinIBA 01/2018
1	nobiletinIBA 12/2017
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 11/2016
1	Co-Repressor ProteinsIBA 01/2016

Therapy/Procedure

12	Therapeutics 02/2021 - 05/2007
1	Drug Therapy (Chemotherapy) 01/2021